abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:Phosphoinositides and phosphoinositide binding proteins play a critical role in membrane and protein trafficking in eukaryotes. Their critical role in replication of cytoplasmic viruses has just begun to be understood. Poxviruses, a family of large cytoplasmic DNA viruses, rely on the intracellular membranes...

journal_title：Journal of virology

authors： Kolli S,Meng X,Wu X,Shengjuler D,Cameron CE,Xiang Y,Deng J

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:The interaction between viruses and immune cells of the host may lead to modulation of intracellular signaling pathways and to subsequent changes in cellular behavior that are of benefit for either virus or host. ERK1/2 (extracellular signal regulated kinase 1/2) signaling represents one of the key cellular ...

journal_title：Journal of virology

authors： Setas Pontes M,Devriendt B,Favoreel HW

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:To date, the response of teleost B cells to specific pathogens has been only scarcely addressed. In this work, we have demonstrated that viral hemorrhagic septicemia virus (VHSV), a fish rhabdovirus, has the capacity to infect rainbow trout spleen IgM-positive (IgM(+)) cells, although the infection is not pr...

journal_title：Journal of virology

authors： Abós B,Castro R,González Granja A,Havixbeck JJ,Barreda DR,Tafalla C

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:Equine influenza viruses (EIV) are responsible for rapidly spreading outbreaks of respiratory disease in horses. Although natural infections of humans with EIV have not been reported, experimental inoculation of humans with these viruses can lead to a productive infection and elicit a neutralizing antibody r...

journal_title：Journal of virology

authors： Baz M,Paskel M,Matsuoka Y,Zengel J,Cheng X,Treanor JJ,Jin H,Subbarao K

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:Epstein-Barr virus (EBV) is a well-established B-cell-tropic virus associated with various lymphoproliferative diseases of both B-cell and non-B-cell origin. EBV is associated with a number of T-cell lymphomas; however, in vitro studies utilizing prototypical EBV type 1 (EBV-1) laboratory strains have genera...

journal_title：Journal of virology

authors： Coleman CB,Wohlford EM,Smith NA,King CA,Ritchie JA,Baresel PC,Kimura H,Rochford R

更新日期：2015-02-01 00:00:00

abstract：:The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on ...

journal_title：Journal of virology

authors： Joseph U,Linster M,Suzuki Y,Krauss S,Halpin RA,Vijaykrishna D,Fabrizio TP,Bestebroer TM,Maurer-Stroh S,Webby RJ,Wentworth DE,Fouchier RA,Bahl J,Smith GJ,CEIRS H2N2 Working Group.

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

journal_title：Journal of virology

authors： Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

更新日期：2015-01-15 00:00:00

abstract：:Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem,...

journal_title：Journal of virology

authors： Arias CF,Silva-Ayala D,López S

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Marek's disease virus (MDV), an alphaherpesvirus, is the causative agent of a lethal disease in chickens characterized by generalized nerve inflammation and rapid lymphoma development. The extensive colinearity of the MDV genome with those of related herpesviruses has eased functional characterization of man...

journal_title：Journal of virology

authors： Schippers T,Jarosinski K,Osterrieder N

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Many coxsackievirus B (CVB) isolates bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR). However, the virus does not interact with murine DAF. To understand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in whi...

journal_title：Journal of virology

authors： Pan J,Zhang L,Organtini LJ,Hafenstein S,Bergelson JM

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important roles in viral replication, viral latency, and immune escape. The presence of auxiliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is unknown. Simian T-cell l...

journal_title：Journal of virology

authors： Turpin J,Journo C,Ko NL,Sinet F,Carpentier A,Galioot A,Edwards D,Vandamme AM,Gazzolo L,Duc Dodon M,Gessain A,Kashanchi F,Balansard I,Lacoste R,Mahieux R

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus with latent and lytic reactivation cycles. The mechanism by which KSHV evades the innate immune system to establish latency has not yet been precisely elucidated. Toll-like receptors (TLRs) are the first line of defense against viral ...

journal_title：Journal of virology

authors： Zhao Q,Liang D,Sun R,Jia B,Xia T,Xiao H,Lan K

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular proteins to execute their functions. Identification and understanding of these factors would increase our knowledge of the molecular mechanisms manipulated by the viruses. In this s...

journal_title：Journal of virology

authors： Gao S,Wu J,Liu RY,Li J,Song L,Teng Y,Sheng C,Liu D,Yao C,Chen H,Jiang W,Chen S,Huang W

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The accessory gene vpr, common to all primate lentiviruses, induces potent G2/M arrest in cycling cells. A recent study showed that human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) mediates this through activation of the SLX4/MUS81/EME1 exonuclease complex that forms part of the Fanconi anem...

journal_title：Journal of virology

authors： Berger G,Lawrence M,Hué S,Neil SJ

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis. To identify factors associated with maturation-dependent restriction of virus replication, we studied AP-7 rat olfactory bulb neuronal cells, which can dif...

journal_title：Journal of virology

authors： Schultz KL,Vernon PS,Griffin DE

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if similar me...

journal_title：Journal of virology

authors： Remmerswaal EB,Klarenbeek PL,Alves NL,Doorenspleet ME,van Schaik BD,Esveldt RE,Idu MM,van Leeuwen EM,van der Bom-Baylon N,van Kampen AH,Koch SD,Pircher H,Bemelman FJ,Ten Brinke A,Baas F,Ten Berge IJ,van Lier RA,de Vries

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen. In the present study, we developed efficient infectious cell cult...

journal_title：Journal of virology

authors： Li YP,Ramirez S,Mikkelsen L,Bukh J

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces significant airway morbidity. Despite the relevance of hMPV as a pathogen, many aspects of the immune response to this virus are still largely unknown. In this report, we focus on the antiviral immune respon...

journal_title：Journal of virology

authors： Baños-Lara Mdel R,Harvey L,Mendoza A,Simms D,Chouljenko VN,Wakamatsu N,Kousoulas KG,Guerrero-Plata A

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. The majority of norovirus outbreaks are caused by genogroup II.4 (GII.4). Novel GII.4 strains emerge every 2 to 4 years and replace older variants as the dominant norovirus. Novel variants emerge through a combination of recombin...

journal_title：Journal of virology

authors： Vega E,Donaldson E,Huynh J,Barclay L,Lopman B,Baric R,Chen LF,Vinjé J

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Woodchuck hepatitis virus (WHV), a close relative of human hepatitis B virus (HBV), has been a key model for disease progression and clinical studies. Sequences of the assembly domain of WHV and HBV core proteins (wCp149 and hCp149, respectively) have 65% identity, suggesting similar assembly behaviors. We r...

journal_title：Journal of virology

authors： Kukreja AA,Wang JC,Pierson E,Keifer DZ,Selzer L,Tan Z,Dragnea B,Jarrold MF,Zlotnick A

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Pattern recognition receptors (PRR) sense certain molecular patterns uniquely expressed by pathogens. Retinoic-acid-inducible gene I (RIG-I) is a cytosolic PRR that senses viral nucleic acids and induces innate immune activation and secretion of type I interferons (IFNs). Here, using influenza vaccine antige...

journal_title：Journal of virology

authors： Kulkarni RR,Rasheed MA,Bhaumik SK,Ranjan P,Cao W,Davis C,Marisetti K,Thomas S,Gangappa S,Sambhara S,Murali-Krishna K

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Cavally virus (CavV) and related viruses in the family Mesoniviridae diverged profoundly from other nidovirus lineages but largely retained the characteristic set of replicative enzymes conserved in the Coronaviridae and Roniviridae. The expression of these enzymes in virus-infected cells requires the extens...

journal_title：Journal of virology

authors： Blanck S,Stinn A,Tsiklauri L,Zirkel F,Junglen S,Ziebuhr J

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

journal_title：Journal of virology

authors： Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Since the 1960s, simian hemorrhagic fever virus (SHFV; Nidovirales, Arteriviridae) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identifica...

journal_title：Journal of virology

authors： Bailey AL,Lauck M,Sibley SD,Pecotte J,Rice K,Weny G,Tumukunde A,Hyeroba D,Greene J,Correll M,Gleicher M,Friedrich TC,Jahrling PB,Kuhn JH,Goldberg TL,Rogers J,O'Connor DH

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Translation machinery is a major recipient of the principal mitogenic signaling networks involving Raf-ERK1/2 and phosphoinositol 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR). Picornavirus internal ribosomal entry site (IRES)-mediated translation and cytopathogenic effects are susceptible to the st...

journal_title：Journal of virology

authors： Brown MC,Dobrikov MI,Gromeier M

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccinated individuals frequently produce antibodies specific for ...

journal_title：Journal of virology

authors： Acharya P,Tolbert WD,Gohain N,Wu X,Yu L,Liu T,Huang W,Huang CC,Kwon YD,Louder RK,Luongo TS,McLellan JS,Pancera M,Yang Y,Zhang B,Flinko R,Foulke JS Jr,Sajadi MM,Kamin-Lewis R,Robinson JE,Martin L,Kwong PD,Guan

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that coordinate the virus assembly process. The matrix proteins link the viral glycoproteins and the viral ribonucleoproteins at virus assembly sites and often recruit host machinery that facilitates the budding process. Using a co-...

journal_title：Journal of virology

authors： Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the HIV-1 membrane and induce its disruption and/or deformation during the process. Howeve...

journal_title：Journal of virology

authors： Apellániz B,Rujas E,Carravilla P,Requejo-Isidro J,Huarte N,Domene C,Nieva JL

更新日期：2014-11-01 00:00:00

abstract：:The question of whether any mammalian cells are able to mount an effective RNA interference-mediated antiviral innate immune response has remained highly controversial. In this Gem, I review recent data addressing this important issue and propose a testable hypothesis that can explain many of the apparently contradict...

journal_title：Journal of virology

authors： Cullen BR

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Bluetongue is one of the major infectious diseases of ruminants and is caused by bluetongue virus (BTV), an arbovirus existing in nature in at least 26 distinct serotypes. Here, we describe the development of a vaccine platform for BTV. The advent of synthetic biology approaches and the development of revers...

journal_title：Journal of virology

authors： Nunes SF,Hamers C,Ratinier M,Shaw A,Brunet S,Hudelet P,Palmarini M

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Ebola virus (EBOV) belongs to the group of nonsegmented negative-sense RNA viruses. The seven EBOV genes are separated by variable gene borders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide) IR, and gene overlaps, where the neighboring gene end and start signal...

journal_title：Journal of virology

authors： Brauburger K,Boehmann Y,Tsuda Y,Hoenen T,Olejnik J,Schümann M,Ebihara H,Mühlberger E

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

journal_title：Journal of virology

authors： Dai X,Gong D,Wu TT,Sun R,Zhou ZH

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Understanding the entry and trafficking mechanism(s) of recombinant adeno-associated virus (rAAV) into host cells can lead to evolution in capsid and vector design and delivery methods, resulting in enhanced transduction and therapeutic gene expression. Variability of findings regarding the early entry pathw...

journal_title：Journal of virology

authors： Weinberg MS,Nicolson S,Bhatt AP,McLendon M,Li C,Samulski RJ

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head syndrome in chickens. Since its discovery in the 1970s, aMPV has been recognized as an economically important pathogen in the pou...

journal_title：Journal of virology

authors： Sun J,Wei Y,Rauf A,Zhang Y,Ma Y,Zhang X,Shilo K,Yu Q,Saif YM,Lu X,Yu L,Li J

更新日期：2014-11-01 00:00:00

abstract：:In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and vir...

journal_title：Journal of virology

authors： Raposo RA,Abdel-Mohsen M,Deng X,Hecht FM,Pilcher CD,Pillai SK,Nixon DF

更新日期：2014-10-01 00:00:00

abstract：UNLABELLED:Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor required by IAV for successful entry into target cells. PEPD was selected as a candidate during an entry screen ...

journal_title：Journal of virology

authors： Pohl MO,Edinger TO,Stertz S

更新日期：2014-10-01 00:00:00

abstract：:To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed ...

journal_title：Journal of virology

authors： Deng X,Agnihothram S,Mielech AM,Nichols DB,Wilson MW,StJohn SE,Larsen SD,Mesecar AD,Lenschow DJ,Baric RS,Baker SC

更新日期：2014-10-01 00:00:00

abstract：:Genetic and phylogenetic analyses suggest that the pandemic H1N1/2009 virus was derived from well-established swine influenza lineages; however, there is no convincing evidence that the pandemic virus was generated from a direct precursor in pigs. Furthermore, the evolutionary dynamics of influenza virus in pigs have ...

journal_title：Journal of virology

authors： Wei K,Sun H,Sun Z,Sun Y,Kong W,Pu J,Ma G,Yin Y,Yang H,Guo X,Chang KC,Liu J

更新日期：2014-10-01 00:00:00